Int J Thyroid Res | Volume 1, Issue 1 | Research Article | Open Access

Non-Thyroidal Illness Syndrome in Primary Hyperparathyroidism

Mustafa Caliskan1, Selvihan Beysel1,2*, Bekir Ucan1, Muhammed Kizilgul1, Seyfullah Kan1, Mustafa Ozbek1 and Erman Cakal1

1Department of Endocrinology and Metabolism, Diskapi Yildirim Beyazit Teaching and Research Hospital, Turkey
2Department of Medical Biology, Baskent University, Turkey

*Correspondance to: Selvihan Beysel 

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Introduction: Primary Hyperparathyroidism (PHPT) is associated with chronic inflammation and metabolic disorders. Although NTIS is associated with critical illness disorders, the association between NTIS and PHPT has not been investigated. We aimed to investigate the presence of NTIS in PHPT patients.
Methods: The cross-sectional study included thirty-four patients with PHPT and 58 age- and gendermatched controls. Serum free triiodothyronine (T3), free thyroxine (T4), Thyroid-Stimulating Hormone (TSH), high sensitivity C-reactive protein (hs-CRP) was compared between groups.
Results: Serum glucose, insulin, HOMA-IR and lipids were higher in PHPT than in controls (p<0.05). Serum TSH value did not differ between PHPT group and control (1.74 ± 0.21 vs. 1.89 ± 0.19 μ IU/mL, p>0.05). Serum sT3 (2.91± 0.07 vs. 2.95 ± 0.08 pg/mL, p>0.05) and sT4 (1.0 ± 0.02 vs. 1.13 ± 0.02 ng/dL, p>0.05) value did not differ between PHPT group and control. NTIS did not observe in both patients with PHPT and controls. hs- CRP was higher in PHPT group than in controls (2.33 ± 037 vs. 1.54 ± 0.35 mg/L, p=0.034). hs- CRP was positively correlated with iPTH value (r=0.35, p=0.02).
Conclusion: NTIS response did not represent in PHPT, independent of chronic inflammation (hsCRP) and metabolic disorders. Although chronic inflammatory state and metabolic disorders is observed in patients with PHPT, NTIS is not associated with PHPT.


Hyperparathyroidism; Non-Thyroidal Illness Syndrome; Metabolic Disorders; Inflammation


Caliskan M, Beysel S, Ucan B, Kizilgul M, Kan S, Ozbek M, et al. NonThyroidal Illness Syndrome in Primary Hyperparathyroidism. Int J Thyroid Res. 2018; 1(1): 1003.

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