Arch Gastroenterol Case Rep | Volume 1, Issue 1 | Case Study | Open Access

Hypertrophic Gastric Mucosa Related to GastrinProducing Neuroendocrine Tumor of Pancreas

Iori Motoo, Takayuki Ando, Hiroki Yoshita and Toshiro Sugiyama*

Department of Gastroenterology and Hematology, University of Toyama, Japan

*Correspondance to: Toshiro Sugiyama 

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Abstract

Major manifestation of gastrinoma (NET-G1) is frequently gastro-duodenal ulcers and hypergatrinemia. Additionally, hypertrophic gastric mucosa in the areas with oxyntic glands is commonly observed. Because gastrin itself has no direct trophic action to the gastric epithelial cells in the stomach, the other growth factors are contributing to the gastric mucosal hypertrophy. Here, a high expression of TGF-α was observed in the gastric epithelial cells, which suggests that the produced TGF-α may partially contribute to mucosal hypertrophy via an autocrine or paracrine mechanism in human tissues with NET-G1.

Citation:

Motoo I, Ando T, Yoshita H, Sugiyama T. Hypertrophic Gastric Mucosa Related to Gastrin-Producing Neuroendocrine Tumor of Pancreas. Arc Gastroenterol Case Rep. 2018; 1(1): 1001.

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