Fatih Büyüker1, Hatice Seneldir2, Cem Ilgin Erol1, Metin Leblebici1*, Mehmet Sait Ozsoy1, Gurhan Bas1 and Orhan Alimoglu1
1Department of General Surgery, İstanbul Medeniyet University, Istanbul, Turkey
2Department of Pathology, İstanbul Medeniyet University, İstanbul, Turkey
Ampullary adenocarcinomas are extremely rare tumors and constitute approximately 0.2% of all gastrointestinal malignancies. Signet ring cell variant of ampullary tumors is much rarer and has a poor prognosis, and chemotherapy has been reported to have no effect on survival. In this study, a 68-year-old male patient with Signet Ring cell Ampullary Adenocancer (SRCA) is presented. Radiologically, an ampullary mass was detected in the patient admitted to the emergency department with abdominal pain, nausea, vomiting, and jaundice. Histopathological examination revealed ampullary signet ring cell carcinoma. There was no metastasis and the tumor was resectable in radiological evaluation, so the patient underwent Pylorus Preserving Pancreaticoduodenectomy (PPPD). The patient was discharged without complications on the 12th postoperative day. Histopathological evaluation revealed that the tumor was T4N1, and adjuvant chemotherapy was recommended to the patient, but the patient refused chemotherapy. No recurrence was detected in the postoperative 4 years follow-up.
Ampulla of Vater; General surgery; Hepatobiliary; Signet ring cell carcinoma
Büyüker F, Seneldir H, Ilgin Erol C, Leblebici M, Sait Ozsoy M, Bas G, et al. Signet Ring Cell Carcinoma of the Ampulla of Vater: Report of a Case with Long-Term Survival. Ann Surg Case Rep. 2022; 5(1): 1056..