Ann Stem Cells Regen Med | Volume 1, Issue 1 | Mini Review | Open Access

The Effect of Platelet-Rich Plasma on the Chondrogenic and Osteogenic Differentiation of Stem Cells

Andrea Pantalone^1*, Alessio Giannetti¹, Daniele Vanni¹, Sandra Verna², Patrizia Di Gregorio² and Vincenzo Salini¹

¹Department of Medicine and Science of Aging, University of Study “G. d’Annunzio”, Italy
²Department of Immunohaematology and Transfusional Medicine Service, "Ss. Annunziata" Hospital, Italy

^*Correspondance to: Andrea Pantalone 

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Abstract

Tissue engineering is intended to regenerate the damaged organs or to promote their healing. The techniques used by this branch of regenerative medicine consist in biological active molecules, stem cells and scaffolds. Platelet-Rich Plasma (PRP) is a plasma fraction containing an amount of platelets several times above the baseline. In the last decades the use of PRP has gained popularity in the field of the tissue engineering. Its properties are anti-inflammatory, analgesic and neoangiogenetic; for this reason it is able to promote tissue formation and remodeling by influencing stem cells migration, proliferation and differentiation. Stem cells used in tissue engineering are harvested from different sources. In orthobiologics, the application of the regenerative medicine in the orthopedic field, Mesenchymal Stem Cells (MSCs) from bone marrow are the most used. Nevertheless there are other alternative sources of MSCs that can be chosen such as adipose tissue, synovial fluid, muscle tissue, umbilical cord and amniotic fluid. The aim of this mini-review is to collect the works present in literature where PRP has been used in combination with stem cells from different origins: this association has shown promising results both in vitro, in chondrogenic and osteogenic differentiation and in vivo, in osteochondral defects healing.

Keywords:

Platelet rich plasma; Orthobiologics; Stem cells; Mesenchymal stem cells

Citation:

Pantalone A, Giannetti A, Vanni D, Verna S, Di Gregorio P, Salini V. The Effect of Platelet-Rich Plasma on the Chondrogenic and Osteogenic Differentiation of Stem Cells. Annals Stem Cell Regenerat Med. 2018;1(1):1003.