Ann Stem Cell Res Ther | Volume 2, Issue 3 | Review Article | Open Access

Immune Properties of Human Dental Pulp Stem Cells and Interactions with the Immune System

Hamada Attoumani¹, Michel Drancourt¹ and Eric Ghigo^2*

¹Department of Emerging Infectious and Tropical Diseases, Aix-Marseille University, France
²Department of Emerging Infectious and Tropical Diseases, Scientific Research National Center, France

^*Correspondance to: Eric Ghigo 

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Abstract

Dental Pulp Stem Cells (DPSCs) are mesenchymal stem cells well known by the scientific community thanks to the studies about their regenerative properties. This regenerative capacity is mainly due to their ability to differentiate into multi-lined cells and their self-renewal. Since their isolation by Gronthos in 2000, their regenerative capacity has been intensively studied in relation to immunity. Thus, several studies have reported about the immune properties of DPSCs. Nevertheless, little is known about the mechanism of action that DPSCs exert in their micro-environment and their interactions with immune cells. The purpose of this review is to summarize the set of knowledge on the immune properties of DPSCs and their interactions with immune cells.

Keywords:

Dental pulp stem cells (DPSC); Immunity; Immunomodulatory; TLRs; NF-kb

Citation:

Attoumani H, Drancourt M, Ghigo E. Immune Properties of Human Dental Pulp Stem Cells and Interactions with the Immune System. Ann Stem Cell Res Ther. 2018; 2(3): 1018.