Ann Short Rep | Volume 3, Issue 2 | Research Article | Open Access

Molecular and Histopathological Characteristics in Colorectal Cancer Patients with Family History of Cancer: A Case Series of Nine Patients with Review of Literature

Alka Y¹, Ashok K^1*, Niraj K² and Preeti B³

¹Department of Surgical Gastroenterology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, India
²Department of Pathology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, India
³Department of Biosciences, Integral University, India

^*Correspondance to: Ashok Kumar 

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Abstract

Family history of Colorectal Cancer (CRC) is a known risk factor for CRC and holds within both genetic and environmental risk. Limited data from India are available on the patients with family history of cancer which suggests a differential age or stage at cancer diagnosis and also there are mixed evidence on histopathological and molecular characteristics. This study was aimed to find out the histopathological and molecular characteristics of histopathologically confirmed colorectal cancer patients with familial history of cancer. MSI analysis and immunohistochemical staining were used to detect the mutation in Mismatch repair genes (MLH1, MSH2, MSH6 and PMS2). In this study, there were 8 males and 1 female patient. Age range of the patients was 24 years to 77 years. Our study revealed that patients with history of cancer in their families were relatively young had advanced disease (Stage III and IV) and revealed comparatively more Microsatellite instable phenotype, poor degree of differentiation and poorer prognostic factor

Keywords:

Colorectal Cancer (CRC); Family history of cancer; Immunohistochemistry (IHC); Microsatellite Instability (MSI), Histopathological features

Citation:

Alka Y, Ashok K, Niraj K, Preeti B. Molecular and Histopathological Characteristics in Colorectal Cancer Patients with Family History of Cancer: A Case Series of Nine Patients with Review of Literature. Ann Short Reports. 2020; 3: 1054.