Ann Radiat Ther Oncol | Volume 1, Issue 1 | Review Article | Open Access

SASPects of Radiation Induced Senescence

Luigi Minafra^1*, Valentina Bravatà¹, Francesco Paolo Cammarata¹, Federica Maria Di Maggio² and Giusi Irma Forte¹

¹Institute of Molecular Bio-imaging and Physiology (IBFM)-CNR, Italy
²Department of Pathobiology and Medical Biotechnologies, University of Palermo, Italy

^*Correspondance to: Luigi Minafra 

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Abstract

Cellular senescence is a complex process of irreversible growth arrest which contributes to several physiological and pathological conditions. A variety of intrinsic or extrinsic stress signals, including those induced by Radiation Therapy (RT) also in combination with chemotherapeutic drugs, are able to cause stress-induced premature senescence in cancer cells (known as Therapy-Induced Senescence, TIS). Although TIS may inhibit tumor growth following RT, a number of outstanding issues about long-term tumor control and recurrence still remain unclear. The aim of this review is to describe the principal aspects of radiation induced senescence, the molecular pathways involved and the Senescence-Associated Secretory Phenotype (SASP). Finally, we report some therapeutic applications with the use of targeted molecules in TIS approaches.

Citation:

Minafra L, Bravatà V, Cammarata FP, Di Maggio FM, Forte GI. SASPects of Radiation Induced Senescence. Ann Radiat Ther Oncol. 2017; 1(1): 1006.