Ann Mult Scler Res | Volume 1, Issue 1 | Mini Review | Open Access

Multiple Sclerosis and Familial Mediterranean Fever: Myth or Reality?

Salem Bouomrani^1,2* and Mouna Guermazi^1,2

¹Department of Internal Medicine, Military Hospital of Gabes, Gabes 6000, Tunisia
²Sfax Faculty of Medicine, University of Sfax, Sfax 3029, Tunisia

^*Correspondance to: Salem Bouomrani 

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Abstract

For a long time controversial, the association between Familial Mediterranean Fever (FMF) and Multiple Sclerosis (MS) seems to be more and more obvious and confirmed. Both diseases share mainly genetic predisposition and recurrent inflammation with pro-inflammatory hypercytokinemia as contributing pathophysiological factors. The specific mutation of the MEFV gene responsible for FMF also seems to have a direct implication in the development of MS. In this mini review we discuss this association and its various plausible mechanisms

Keywords:

Familial mediterranean fever; Multiple sclerosis; Association; MEFV gene mutation; Pyrin

Citation:

Bouomrani S, Guermazi M. Multiple Sclerosis and Familial Mediterranean Fever: Myth or Reality? Ann Mult Scler Res. 2019; 1(1): 1003.