Ann Microbiol Immunol | Volume 1, Issue 2 | Short Communication | Open Access

Aflatoxin B1 Inhibits the Replication of Chandipura Virus in Human Hepatoma Cells

Mohamed Mutocheluh* and Patrick W Narkwa

Department of Clinical Microbiology, Kwame Nkrumah University of Science and Technology, Kumasi-Ghana

*Correspondance to: Mohamed Mutocheluh 

Fulltext PDF

Abstract

We previously showed that aflatoxin B1 inhibited the antiviral type 1 interferon signalling response pathway as a mechanism of hepatocellular carcinoma. The type I interferon signalling is part of the innate immune system that defends the body against invading microorganisms. The consequence of compromising or suppressing the immune system include increased susceptibility to infectious diseases, reactivation of chronic diseases as well as increased susceptibility to cancers. Therefore, the chandipura virus was selected as a model virus to test the hypothesis that aflatoxin B1 would enhance viral replication in patients presenting with viral infections and long exposure to dietary aflatoxin. The chandipura viral titre was quantified in the presence or absence of aflatoxin B1 by plaque assay using L929 cells and stained with crystal violet. The data presented in this research notes is a side product of another research of which the results have been published. The current study showed aflatoxin B1 (10 μM) reduced the replication of chandipura virus and the rate of reduction was exacerbated in the presence of interferon. The results open avenues for further studies to understand the interplay between viral infections and aflatoxins in accelerating cancers such as the hepatocellular carcinoma.

Keywords:

Aflatoxin B1; Chandipura virus; HepG2; Type I interferon pathway

Citation:

Mutocheluh M, Narkwa PW. Aflatoxin B1Inhibits the Replication of Chandipura Virus in Human Hepatoma Cells. Ann Microbiol Immunol. 2018; 1(2): 1008.

Subscribe to Our Newsletter