Ann Med Med Res | Volume 5, Issue 1 | Research Article | Open Access
Jie Li, Haozong Zhao, Cong Xia, Qianshi Zhang* and Shuangyi Ren*
Department of Gastrointestinal Surgery, The Second Affiliated Hospital of Dalian Medical University, PR China
*Correspondance to: Shuangyi Ren
Fulltext PDFBackground: Systemic inflammation and nutritional status have been implicated as predictors of
cancer outcome. As indicators of systemic inflammatory response, Neutrophil/Lymphocyte Ratio
(NLR) and Prognostic Nutritional Index (PNI) have been proposed to predict the clinical outcome
of certain cancers. The purpose of this study was to investigate the effect of PNI and NLR on the
prognosis of gastric cancer.
Methods: From 2010 to 2018, 559 consecutive patients undergoing radical surgery for gastric
cancer were enrolled. The optimal cut-off values for PNI and NLR were determined according to
the receiver operating characteristic analysis. According to the cut-off value, we categorized the
patients into the high or low PNI and NLR groups, and the clinical characteristics of the two groups
were compared and analyzed.
Results: PNI was an independent prognostic factor for overall survival in patients with gastric
cancer, while NLR was not.
Conclusion: Although both PNI and NLR reflect prognosis, PNI is a better predictor of overall
survival in patients with gastric cancer than NLR.
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Li J, Zhao H, Xia C, Zhang Q, Ren S. Preoperative Prognostic Nutritional Index (PNI) Predicts Better Prognosis than Neutrophil Lymphocyte Ratio (NLR) in Patients with Gastric Cancer. Ann Med Medical Res. 2022; 5: 1048..