Ann Med Med Res | Volume 5, Issue 1 | Research Article | Open Access
Hai-Cheng Ye*#, Xiao-Jun Fan#, Chun-Tao Su, Jing-Xiong Lin, Qi Chen, Shu-Qiang Chen, Wen-Yang Zhang and Guo-Xin Ni*
Department of Rehabilitation Medicine, The First Affiliated Hospital of Xiamen University, China
*Correspondance to: Hai-Cheng Ye
Fulltext PDFBackground: Post-Stroke Cognitive Impairment (PSCI) undermines health and life quality
substantially. The present study aimed at clarifying the benefits of Computer-Based Cognitive
Flexibility Training (CBCT) for the mitigation of this condition.
Methods: Sixty patients with PSCI were randomly allocated into the CBCT group (RehaCom
training, 45 min/day, 5 days/week for 12 weeks) or control group (no cognitive intervention).
Global cognitive function was measured using Mini-Mental State Examination (MMSE), Montreal
Cognitive Assessment (MoCA), and P300.
Results: Totally 8 patients dropped out of the study, so there were 27 and 25 patients in the
cognitive training and control groups going round the course, respectively. Inter-group comparison
demonstrated that the training group had lower MMSE or MoCA scores (p=0.004, p=0.000), higher
P300 amplitudes (p=0.000), and shorter P300 latency (p=0.008) than the control group. To validate
the efficacy of CBCT and traditional measures, the intra-group comparison was performed, which
evinced that the MMSE and MoCA scores as well as the P300 amplitudes were markedly increased
while the P300 latency was significantly decreased after either of the interventions (p<0.01).
Conclusion: CBCT improved the global cognitive function markedly in patients suffering from
PSCI.
Stroke; Cognitive impairment; Rehabilitation; Compensational strategy; CBCT
Ye H-C, Fan X-J, Su C-T, Lin J-X, Chen Q, Chen S-Q. The Effect of Computer-Based Cognitive Flexibility Training on
Recovery of Global Cognitive Function after Stroke. Ann Med Medical Res. 2022; 5: 1041..