Shahzad Ahmad1, Afsheen Mahmood2, Hamad Haider Khan3, Hameed Ullah4, Gulsanga Ayub5, Mohammad Sajjad Ali6, Asad Khan7 and Abdul Wahid7*
1Department of Medicine, Northwest General Hospital, Pakistan 2Department of Physiology, Khyber Girls Medical College, Pakistan 3Department of Endocrinology, First Affiliated Hospital, Xian Jiaotong University, China 4Department of Cardiology, First Affiliated Hospitals, Xian Jiaotong University, China 5Department of Radiology, Combined Military Hospital, Pakistan 6Department of Medicine, Northwest General Hospital, Pakistan 7Department of Pharmacy and Health Sciences, University of Balochistan, PakistanFulltext PDF
Objectives: To determine the prevalence of Helicobacter pylori seropositivity in patients of hepatic cirrhosis with hepatic encephalopathy. Study design: Descriptive cross-sectional study. Place and duration of study: This study was conducted at the Department of Medicine, Northwest General Hospital & Research Center, Peshawar, KPK, from 2nd June 2016 to 2nd December 2016. Materials and Methods: The study was conducted at Northwest General Hospital & Research center from 2nd June 2016 to 2nd December 2016 on 137 patients after the permission of the hospital ethical committee. The collection of data regarding the patients with liver cirrhosis having encephalopathy presenting to the outpatient department/causality of this institute. The patients were informed and their written consent was taken from patients (age 15 and above) with full work-up of comprehensive clinical history and for physical examination. The 5 ml blood was obtained under aseptic condition, sent to the laboratory for H. pylori antibodies detection. Results: The mean ages of the patients were 41.36 years ± 10.48 SD and 62 (45.55%) were female and 75 (54.75%) were male and H. pylori-positive was found in 94 (68.61%). Encephalopathy grade wise distribution of patients shows that 25 (18.25%) patients have grade 1, 33 (24.09%) were grade 2, 40 (29.2%) were grade 3 and 39 (28.47%) have grade 4 encephalopathy. Conclusion: Helicobacter pylori antibodies showed a high titer in patients with Porto-systemic encephalopathy due to cirrhosis. This may suggest that presence of Helicobacter pylori may play some part or may amplify the pathogenesis of hepatic encephalopathy in patients with liver cirrhosis.
H. pylori; Hepatic encephalopathy; ELISA; Liver disease
Ahmad S, Mahmood A, Khan HH, Ullah H, Ayub G, Sajjad Ali M, et al. Helicobacter pylori as Initiating Factor in Patients of Cirrhosis with Concomitant Hepatic Encephalopathy. Ann Med Medical Res. 2020;3:1031..