Ann Med Med Res | Volume 7, Issue 1 | Review Article | Open Access

Harnessing the Role of Transient Receptor Potential (TRP) Channels as Pathogen Sensors: Potential for Novel Therapeutic Interventions?

Protiti B^* and Prabha D

Department of Microbiology, Bhopal Memorial Hospital and Research Centre, India

^*Correspondance to: Protiti Bose 

Abstract

The role of Transient Receptor Potential (TRP) channels as pathogen sensors presents a compelling narrative in understanding cellular defense mechanisms against microbial invasion. We dwell on the intricate interplay between TRP channels and pathogen recognition, elucidating their pivotal role in initiating immune responses. TRP channels are recognized for their multifaceted responsiveness to various environmental cues, thereby emerging as key players in detecting pathogenic components. Upon stimulation by pathogenic cues, TRP channels undergo conformational changes or activation, initiating a cascade of intracellular events. This activation prompts the influx of ions, predominantly calcium, into the cell, culminating in the activation of downstream signaling pathways. These signaling cascades orchestrate a robust immune response, encompassing the activation of immune cells, the release of cytokines, and the priming of neighboring cells to fortify their defenses against the invading pathogens. Understanding the intricacies of TRP channels as pathogen sensors unveils promising avenues for therapeutic interventions. Targeting these channels holds potential for manipulating immune responses, developing strategies to bolster the host's defense against infections, and potentially mitigating immune-related disorders.

Keywords:

Bacterial endotoxin; Lipopolysaccharides; Transient receptor potential; Pathogenassociated molecular patterns

Citation:

Protiti B, Prabha D. Harnessing the Role of Transient Receptor Potential (TRP) Channels as Pathogen Sensors: Potential for Novel Therapeutic Interventions?. Ann Med Medical Res. 2024; 7: 1078..