Ann Integrative Oncol | Volume 2, Issue 1 | Review Article | Open Access

A Novel Theory of Classifying Disease with Potential for Diagnosis, Prophylaxis, and Therapeutic Approaches

Natalia Chaikovskaia1 *, Natalya V Khmil2 and Homer S Black3

1Scientific and Production Association Oxygen Ltd., Smolensk, Russia 2 Moscow Institute, Moscow, Russia 3 Baylor College of Medicine, Houston, Texas, USA

*Correspondance to: Natalia Chaikovskaia 

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Early medical theory, appearing at different times and locales, proposed that good health was manifested in an equilibrium (homeostasis) of one’s protective mechanism complex and offending stress agents. The protective complex includes the immune, biochemical, and other systems of the body. Stress factors may involve endogenous factors, e.g., steroid hormones, catecholamines, hypoxia, inflammation, etc.; exogenous factors, e.g., drugs, carcinogens, mutagens, allergens, and environmental agents; and anthropogenic loadings, e.g., smoking, excess drinking, etc. Under the influence of these stress factors, the defense mechanism(s) may be unable to neutralize induced changes in the internal organ environment and visible symptoms of “disease” begin to appear. Based upon the body’s failure to restore the resulting imbalanced homeostasis, the overall health condition moves to an inflammatory stage and then to an incipient disease stage I, (dysfunction); followed by disease stages II (degeneration) and stage III (terminal). We propose that identification of these classes of disease can be determined by following lipid hydroperoxide/antioxidant homeostasis, in conjunction with classical clinical diagnosis. Further, measuring antioxidant status has significant diagnostic and treatment prognostic importance in defining the level of organism damage. Collective sera data for a range of disorders from small pelvis inflammation, pneumonia, stomach ulcer, duodenal ulcer, rheumatic diseases, severe bronchial asthma, and liver cirrhosis indicate a progressive decline in antioxidant status and an increase in lipid hydroperoxide level as the destructive disease processes progress. Although a broader data base must be accrued, this approach represents an exciting and important approach to determine disease development and potential means of intervention and therapy (Graphic Abstract).


Lipid hydroperoxide; Antioxidant activity; Lipid peroxide/Antioxidant activity ratio; Disease stage; Homeostasis


Chaikovskaia N, Khmil NV, Black HS. A Novel Theory of Classifying Disease with Potential for Diagnosis, Prophylaxis, and Therapeutic Approaches. Ann Integr Oncol. 2022; 2(1): 1011..

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