Department of Biochemistry, Gulbarga University, IndiaFulltext PDF
To evaluate the anticancer activity of crude methanol extract of Pandanus odoratissimus Linn. on a human oral cancer cell line (KB). Oral cancer is one among the various cancers that affect majority of the population in India. In order to overcome toxicity of chemotherapy and disfiguration through surgical procedures, the researchers are targeting phytochemicals because of their anticancer properties. Cell growth was observed when the methanol extracts was 12.5 μg/mL (32%, 36% and 39%), 25 μg/mL (42%, 45% and 46%), 50 μg/mL (45%, 50% and 55%) and 100 μg/mL (57%, 61% and 62%) after 24 h, 48 h and 72 h treatments respectively, at extract concentrations. The IC50 values of 100 μg/mL, 50 μg/mL and 25 μg/mL were determined for 24 h, 48 h and 72 h treatment, which indicated that the extract is only highly cytotoxic after 72 h treatment. Apoptotic cell death is a highly organized physiological process to eliminate damaged or abnormal cells.
Pandanus odoratissimus; KB cell lines; Apoptotic activity
Kamble A. Antiproliferative and Apoptotic Activity of Crude Methanolic Extract of Pandanus odoratissimus Linn. on Human Oral Cancer Cells. Ann Integr Med. 2020;1(1):1001..