Ann Infertil Reprod Endocrinol | Volume 2, Issue 2 | Case Report | Open Access

Comparisons of Perinatal Outcomes among Naturally Conceived and IVF Conceived (Fresh and Frozen Embryos) Singleton Babies

Adhwaa Khudhri1*, Simon Phillips1,2, Robert Hemmings3, Wael Jamal1,4,5 and Mohammad Zubair Alam6

1OVO Fertility Clinic, Canada
2Department of Obstetrics and Gynecology, University of Montreal, Canada
3Department of Obstetrics and Gynecology, McGill University, Canada
4Department of Medicine, University of Montreal, Canada
5Department of Medicine, Rabigh Campus, King AbdulAziz University, Saudi Arabia
6King Fahd Medical Research Center, King Abdulaziz University, Saudi Arabia

*Correspondance to: Adhwaa Khudhri 

Fulltext PDF


Infertility is a condition with important psychological, economic, demographic and medical implications. Assisted reproductive technologies started nearly four decades ago can help in alleviating the burden of infertility in affected couples. It is estimated that 1% to 3% of children born in developed countries were conceived through these technologies. The majority of babies born with the help of these assisted reproductive technologies are healthy but, in recent years, health concerns of such babies have come to surface. Studies have found that babies conceived through assisted reproduction have an increased risk of adverse perinatal outcomes. This is a retrospective study on perinatal outcome of singleton babies conceived naturally or using three protocols of assisted reproductive techniques between 2010 and 2014. The perinatal outcome such as gestational age, birth weight and various other parameters of singleton babies conceived through Modified Natural In Vitro Fertilization (MNIVF) n=258, In Vitro Fertilization using Controlled Ovarian Stimulation (IVFCOS) n=384, and Frozen Embryo Transfer (FET) n=219 were compared to 19,852 naturallyconceived singleton babies. Significant differences (P<0.05) were observed among the spontaneous pregnancy and MNIVF, IVFCOS as well as FET for gestation age, birth weight and sex ratio. Significant differences (P<0.05) were also observed among women in different protocols for antimullerian hormone levels, ovarian reserve and type of delivery whereas no significant differences were found for BMI, years of infertility and smoking habits. In conclusion, the differences in perinatal outcomes are still found among babies born after different modes of conceptions. Higher gestation age at delivery was seen in the natural conception group whereas average birth weight was found to be higher in the FET conceived group.


Khudhri A, Phillips S, Hemmings R, Jamal W, Alam MZ. Comparisons of Perinatal Outcomes among Naturally Conceived and IVF Conceived (Fresh and Frozen Embryos) Singleton Babies. Ann Infert Rep Endocrin. 2019,2(2):1018..

Subscribe to Our Newsletter