Ann Infect Dis Epidemiol | Volume 4, Issue 2 | Research Article | Open Access

Usefulness of the FilmArray Meningitis/Encephalitis(M/E) Panel for the Diagnosis of Infectious Meningitis and Encephalitis in Marrakech

Rabi Adil^1*, Rokni Taoufik¹, Ihbibane Fatima¹, Rada Nourddine², Draiss Ghizlan², Bourouss Mounir³, Tassi Nora¹, Bouskraoui Mohammed² and Soraa Nabila¹

Rabi Adil^1*, Rokni Taoufik¹, Ihbibane Fatima¹, Rada Nourddine³, Draiss Ghizlan³, Bourouss Mounir⁴, Tassi Nora², Bouskraoui Mohammed³ and Soraa Nabila^1,5

^*Correspondance to: Adil Rabi 

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Abstract

Introduction: Central nervous system infections such as meningitis and encephalitis currently represent a real diagnostic and therapeutic challenge. The objective of this study is to evaluate the contribution of the Film Array Meningitis/Encephalitis (M/E) panel for in the rapid and targeted diagnosis of meningitis and meningoencephalitis at the University Hospital of Marrakech. Materials and Methods: This is a prospective study conducted over a period of one year (February 2018 - February 2019), including all patients with lumbar puncture with a cytology greater than 5 elements/mm3 and patients admitted for suspicion of meningoencephalitis. Results: During this period, 176 lumbar punctures were performed that met the criteria to multiplex PCR, 101 cases for suspicion of meningoencephalitis and 75 cases for suspicion of meningitis. The etiology was confirmed in 23% of the LCS treated for suspicion of meningitis. Bacterial etiology dominated the pattern in 70.5% of cases followed by viral (23.5%) and fungal (6%) etiology. The etiology was confirmed in 14% of the LCS treated for suspicion of meningoencephalitis. Viral etiology dominated the pattern in 81% of cases followed by bacterial (12.5%) and fungal (6%) etiology. Conclusion: Their rapid and efficient diagnosis made it possible to set up an appropriate treatment by avoiding the unnecessary prescription of antibiotics.

Keywords:

Meningitis; Encephalitis; Multiplex PCR

Citation:

Adil R, Taoufik R, Fatima I, Nourddine R, Ghizlan D, Mounir B, et al. Contribution of the Syndromic Approach in the Diagnosis of Meningitis at the University Hospital of Marrakech. Ann Infect Dis Epidemiol. 2019; 4(2): 1045.