Ann Digest Liver Dis | Volume 1, Issue 1 | Research Article | Open Access
Ahmad Farooq Alsayed Hasanain1*, Ali Abdel-Azeem Hasan Zayed2, Samir Kamal Abdel-Hamied3, Amany Mohamed Adawi Nafee4 and Sherif Mohamed Abdel-Aal5
1Department of Tropical Medicine and Gastroenterology, Assiut University, Egypt
2Department of Chest Diseases and Tuberculosis, Assiut University, Egypt
3Department of Internal Medicine (Nephrology Unit), Assiut University, Egypt
4Department of Microbiology and Immunology, Assiut University, Egypt5Department of Diagnostic Radiology, Assiut University, Egypt
*Correspondance to: Ahmad Farooq Alsayed Hasanain
Fulltext PDFBackground/
Aim: Our research hypothesis is that long-term acid suppression can lead to higher susceptibility to Mycobacterium tuberculosis infection due to defective gastric acid barrier. Our study aim was to determine the prevalence of long-term acid suppressive therapy use among patients with Mtb infection and to explore its contribution to the development of infection. Patients and
Methods: A case-control study included 264 patients with newly diagnosed, pulmonary or extrapulmonary TB, consecutively, and an equal number of normal subjects as a control group. For all the enrolled, clinical evaluation (medical history and physical examination), abdominal ultrasonography, chest radiography, and laboratory evaluation were provided. Long-term use of acid suppressive therapy was defined as the use for three months or more, during the year preceding the diagnosis of TB.
Results: The study groups were matching regarding age and gender. The most frequent type was pulmonary TB (65.2%). Omeprazole was the most frequently used acid suppressive agent (39.6%). Factors associated with Mtb infection were diabetes mellitus, chronic obstructive pulmonary disease, long-term corticosteroids use, long-term acid suppressive therapy, liver cirrhosis, renal failure, and congestive heart failure. After adjusting for the cofounding variables, long-term acid suppressive therapy had adjusted or of 2.1 (95% CI 1.4-6.1; p 0.024) for its use among the study cases. Conclusions: In conclusion, the wide use of acid suppressive therapy for long durations (especially PPI) can make the patients more vulnerable to infection with Mtb.
Hasanain AFA, Abdel-Azeem Hasan Zayed A, Abdel-Hamied SK, Adawi Nafee AM, Abdel-Aal SM. Long-Term Acid Suppressive Therapy among Naïve Patients with Mycobacterium Tuberculosis Infection. Ann Digest Liver Dis. 2018; 1(1): 1003.