Ann Diabetes Res | Volume 5, Issue 1 | Research Article | Open Access

Nephroprotective Effect of Tinospora cordifolia and Metformin on Alloxan Induced Diabetic Mice

Sneha Navin¹, Jaykar Jha4, Abhinav¹, Roushan Kumari⁵, Arun Kumar², Ashok Ghosh² and Ranjit Kumar^3*

1School of Biological Engineering and Sciences, Shobhit University Gangoh, India 2Research Centre, Mahavir Cancer Sansthan and Research Centre, India 3Department of Animal Science, Central University of Himachal Pradesh, India 4Department of Biotechnology, L. N. Mithila University, India 5A.N. College, India

^*Correspondance to: Ranjit Kumar 

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Abstract

Diabetes mellitus is a metabolic disease marked by hyperglycemia. The chronic hyperglycemia of diabetes is related with long-term damage, dysfunction, and failure of various organs like, the eyes, kidneys, nerves, heart, and blood vessels. Presence of high blood sugar produces the classical symptoms of polyuria, polydipsia and polyphagia. It is predicted that by 2030, India’s diabetes burden will be almost 87 million people. Present study reports nephroprotective study of T. cordifolia and metformin on histology of kidney and KFT of diabetic mice. Four groups of mice were prepared for comparative study which includes control, diabetic, Tinospora cordifolia and Metformin administered group. Diabetic models were prepared in mice by intraperitoneal administration of single dose of alloxan @120 mg/kg b.w. Alcoholic extract of Tinospora cordifolia was administered @200 mg/kg b.w/day for eight weeks. Metformin were administered @50 mg/kg b.w/day for eight weeks. In diabetic group of mice glucose, urea, uric acid and creatinine in serum were increased. Effective restoration was observed in T. cordifolia administered group in comparison to metformin administered diabetic group of mice. Changes observed in glomerulus, Bowman’s capsule, PCT and DCT were also restored effectively in Tinospora cordifolia administered group. Thus, it was concluded from the study that alcoholic extract of T. cordifolia restores glucose level, KFT and changes in renal corpuscles effectively in comparison to metformin administered group Tinospora cordifolia acts effectively on diabetes mice as good as metformin on biochemical parameters.

Keywords:

Alloxan; Metformin; Tinospora cordifolia; Nephroprotective

Citation:

Navin S, Jha J, Abhinav, Kumari R, Kumar A, Ghosh A, et al. Nephroprotective Effect of Tinospora cordifolia and Metformin on Alloxan Induced Diabetic Mice. Ann Diabetes Res. 2021; 5(1): 1015..