Samuel Akintunde Odediran*, Kayode Ebenezer Awosode, Taiwo Adebomi Adegoke, Ka ilat Ajibola Odebunmi, Bimbola Bolu Oladunjoye, Andrew Adedayo Obasanya, Ifeoluwa Michael Omilani, Kafayat Temitayo Soyinka, Jonathan Uyiosa Ugbo, Abayomi Johnson Ogunleke, Stephen Adeleke Adesida, and Adeleke Clement Adebajo
Department of Pharmacognosy, Obafemi Awolowo University, Ile- Ife, NigeriaFulltext PDF
Objective: The decoctions of Chrysophyllum Albidum Leaf (CAL) and stem bark (CAB), and Citrus Aurantifolia Leaf (LCA) and fruit (FCA) used in Africa for malaria and fevers were evaluated for antimalarial activities. Methods: Their prophylactic, chemosuppresive and curative antiplasmodial activities were assayed individually and variously combined with each other and standard drugs of Pyrimethamine (PYR) and Chloroquine (CQ), using Plasmodium berghei infected mice. Results: Using their ED50 values, standard drugs were significantly (p<0.05) more active than the individual plant extracts, while extracts of C. albidum leaf, C. aurantifolia fruit and C. albidum stem bark had the highest prophylactic, chemosuppresive and curative activities, respectively. Co-administrations of individual plant extracts with PYR gave prophylactic activity comparable (p>0.05) to pyrimethamine, except combination with CAB that gave significantly (p<0.05) lower activity. The CAL+CAB+LCA+FCA combination doubled the mice survival time, similar to PYR. Combinations with CQ significantly lowered suppressive and curative activities of chloroquine and gave no better survival time in mice. No plant-plant extract combinations gave comparable prophylactic and suppressive activities as the standard drugs. Only CAL+FCA and LCA+FCA combinations gave comparable and significantly higher curative activity than CQ, respectively. A 73% of the plant-plant combinations gave a survival time comparable to that of CQ, indicating contributory factor of immune booster. This, rather than higher antiplasmodial activity, may justify the practice of combination of plants in ethnomedicinal malarial therapy. Conclusion: Care should be taken in the concomitant administration of orthodox and herbal drugs and as well in the choice of plants to be combined in herbal drug formulations or decoctions.
Odediran SA, Awosode KE, Adegoke TA, Odebunmi KA, Oladunjoye BB, Obasanya AA, et al. Combinations of Chrysophyllum albidum and Citrus aurantifolia as Antimalarial Agents and their Effects on Orthodox Antimalarial Drugs in Mice. Ann Complement Altern Med. 2020; 2(1): 1007.