Ann Clin Toxicol | Volume 1, Issue 1 | Research Article | Open Access
Haruna Y*, Isah I and Elinge CM
Department of Pure and Applied Chemistry, Kebbi State University of Science and Technology, Nigeria
Fulltext PDFCurrently there is a renewed interest in drugs of natural origin simply because they are green medicine, and green medicine offers safe, effective treatment, minimal or no side effects, easily available, lesser cost and are in great demand in the developed world health care. There is decreasing in the efficacy of many modern drugs used for the control of many infections, also an increase in resistance by several bacteria to various antibiotics and increasing cost of prescribed drugs. This study aims at investigating the phytochemical constituents, and toxicity studies of the aqueous leaves extract of Nelsonia canescens. Results of qualitative phytochemical screening of the aqueous leaves extract of N. canescens showed the presence of alkaloids, phenols, tannins, flavonoids and saponins. The acute toxicity test of the extract N. canescens revealed an oral LD50>2000 mg/kg body weight in mice. The presence of some of the phytochemicals, and the values of the LD50 could explains the plant is being used traditionally for the treatment of a wide range of illnesses such as fever, pain, chickenpox, measles, constipation and gastric ulcer without reports of unwanted effects.
Haruna Y, Isah I, Elinge CM. Median Lethal Dose and Phytochemical Studies of Aqueous Leaves Extract of Blue Pussy Leaf Nelsonia canescens (Lam.) Spreng. Ann Clin Toxicol. 2018; 1(1): 1010.