Ann Clin Toxicol | Volume 1, Issue 1 | Research Article | Open Access

Expression of Stress Proteins Induced by Cadmium "In Vivo" and "In Vitro" and the Search for the Protective Effect of Magnesium in In Vitro Culture

Manel Boujelben¹, Raed Abdennabi^2,3*, Amine Elgheryeni⁴ and Abdelfattah El Fekⁱ¹

¹Laboratory of Animal Ecophysiology, Tunisia
²Laboratory of Plant Biotechnology, University of Sfax, Tunisia
³Laboratory of Pharmacognosy and Natural Products Chemistry, Greece
⁴University of Toulouse Jean Jaurès, France

^*Correspondance to: Raed Abdennabi 

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Abstract

Our results show an over expression of HSP 72/73 in the liver, kidneys and testes. This overpressure serves to protect the body against Cd, and is considered as a biomarker of exposure. The in-vitro culture confirms these results where the addition of Cd in the culture medium of A549 cells induces over expression of HSP72. "In-vitro", Mg does not modify Cd-induced HSP expression. "In-vitro" Mg, does not decrease the cytotoxic effect of Cd, and therefore the protective effect of Mg appears to be interacted with the dynamics of absorption, transport and accumulation of Cd in the body, which lowers or decreases its endogenous exposure rates and consequently its toxic effects.

Keywords:

Antioxidant; Biomarqueur; Cadmium; HSP; Oxidative stress

Citation:

Boujelben M, Abdennabi R, Elgheryeni A, El Feki A. Expression of Stress Proteins Induced by Cadmium "In Vivo" and "In Vitro" and the Search for the Protective Effect of Magnesium in In Vitro Culture. Ann Clin Toxicol. 2018; 1(1): 1008.