Giulia Rossetti1,2*, Vanessa Nunziata2 , Pietro Sodani3-11, Rossella Marcucci4 , Samuele Bedetta2 , Anna Maria Di Carlo2 , Michele Tempesta5 , Alberto Rebonato6 , Elena Marini6 , Giancarlo Titolo7 , Giuseppe Visani8 , Martina Chiarucci8 , Filippo Saltamartini9 , Maria Capalbo10 and Gabriele Frausini12
Background: Cerebral Venous Sinus Thrombosis (CVST) and Extracranial Thrombosis (ECT) with thrombocytopenia have been described in Europe following receipt of the VAXZEVRYA (Oxford/ AstraZeneca) vaccination. Objectives: To describe a case of VAXZEVRYA Vaccine-associated Thrombotic Thrombocytopenia syndrome (VITT), to analyze the mechanisms that determines this syndrome and the possible therapeutic strategies. Patients: We report a case of a 75-year-old Caucasian woman, admitted to Fano, internal medicine unit hospital, who developed CVST and portal vein thrombosis, associated with thrombocytopenia following VAXZEVRYA vaccination. We demonstrated the presence of autoantibodies anti-platelet factor 4 (anti-PF4), with a weak functional ability of activate platelets. She received non-heparin anticoagulation treatment, intravenous immunoglobulins at high dosage, dexamethasone and fresh frozen plasma. Results and Conclusion: This case report surely contains the greatest difficulties that a clinic may ever encounter in the management of anticoagulant therapy with severe thrombocytopenia and hemorrhaging complications. More data on the pathogenesis of VITT are needed to optimize the treatment of this rare but often clinically severe thrombotic syndrome associated with VAXZEVRYA vaccinationFulltext PDF
Rossetti G, Nunziata V, Sodani P, Marcucci R, Bedetta S, Di Carlo AM, et al. A Case of VAXZEVRYA Vaccine-Associated Thrombotic Thrombocytopenia Syndrome: Chess Match between Pathophysiology and Therapy. Ann Clin Med Res. 2021; 2(4): 1037.
Rossetti G, Nunziata V, Sodani P, Marcucci R, Bedetta S, Di Carlo AM, et al. A Case of VAXZEVRYA Vaccine-Associated Thrombotic Thrombocytopenia Syndrome: Chess Match between Pathophysiology and Therapy. Ann Clin Med Res. 2021; 2(4): 1037..