Ann Clin Med Res | Volume 2, Issue 4 | Case Series | Open Access

A Case of VAXZEVRYA Vaccine-Associated Thrombotic Thrombocytopenia Syndrome: Chess Match between Pathophysiology and Therapy

Giulia Rossetti^1,2*, Vanessa Nunziata² , Pietro Sodani^3-11, Rossella Marcucci⁴ , Samuele Bedetta² , Anna Maria Di Carlo² , Michele Tempesta⁵ , Alberto Rebonato⁶ , Elena Marini⁶ , Giancarlo Titolo⁷ , Giuseppe Visani⁸ , Martina Chiarucci⁸ , Filippo Saltamartini⁹ , Maria Capalbo¹⁰ and Gabriele Frausini¹²

Background: Cerebral Venous Sinus Thrombosis (CVST) and Extracranial Thrombosis (ECT) with thrombocytopenia have been described in Europe following receipt of the VAXZEVRYA (Oxford/ AstraZeneca) vaccination. Objectives: To describe a case of VAXZEVRYA Vaccine-associated Thrombotic Thrombocytopenia syndrome (VITT), to analyze the mechanisms that determines this syndrome and the possible therapeutic strategies. Patients: We report a case of a 75-year-old Caucasian woman, admitted to Fano, internal medicine unit hospital, who developed CVST and portal vein thrombosis, associated with thrombocytopenia following VAXZEVRYA vaccination. We demonstrated the presence of autoantibodies anti-platelet factor 4 (anti-PF4), with a weak functional ability of activate platelets. She received non-heparin anticoagulation treatment, intravenous immunoglobulins at high dosage, dexamethasone and fresh frozen plasma. Results and Conclusion: This case report surely contains the greatest difficulties that a clinic may ever encounter in the management of anticoagulant therapy with severe thrombocytopenia and hemorrhaging complications. More data on the pathogenesis of VITT are needed to optimize the treatment of this rare but often clinically severe thrombotic syndrome associated with VAXZEVRYA vaccination

^*Correspondance to: Giulia Rossetti 

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Abstract

Rossetti G, Nunziata V, Sodani P, Marcucci R, Bedetta S, Di Carlo AM, et al. A Case of VAXZEVRYA Vaccine-Associated Thrombotic Thrombocytopenia Syndrome: Chess Match between Pathophysiology and Therapy. Ann Clin Med Res. 2021; 2(4): 1037.

Citation:

Rossetti G, Nunziata V, Sodani P, Marcucci R, Bedetta S, Di Carlo AM, et al. A Case of VAXZEVRYA Vaccine-Associated Thrombotic Thrombocytopenia Syndrome: Chess Match between Pathophysiology and Therapy. Ann Clin Med Res. 2021; 2(4): 1037..