Scientific-Hemostasis, Research Laboratory, FranceFulltext PDF
A subset of patients with Covid-19 develops late clinical symptoms or severe complications, with thromboinflammation affecting microcirculation and many organs, in addition to the acute severe respiratory syndrome. Complications occur when neutralizing antibodies are already present and the viral load is low or undetectable. We hypothesized that the SARS-CoV-2 high affinity binding to ACE2 through its spike protein RBD can induce a spreading of the immune response to the self-components involved in this cell entry complex, and especially to ACE2. The long-lasting complications and life-threatening critical illness arising as a rebound effect could be the consequences of autoimmune disease induced by the immune response to SARS-CoV-2. Arguments for supporting that hypothesis are presented, and include characteristics of the disease
course, mechanisms of disease critical evolution, and benefits of some treatments.
Coronavirus; COVID-19; Immune response; Vaccine; Treatment
Amiral J. Can COVID-19 Induce an Autoimmune Disease Associated with Long-Lasting Symptoms and Delayed Complications?. Ann Clin Immunol Microbiol. 2020;2(1):1014..