Ann Clin Immunol MicroBiol | Volume 1, Issue 1 | Case Report | Open Access

Adoration of the Magi: Agammaglobulinemia of the Mother, Clinically Expressed in her Child

Ger T Rijkers^1,2*, Ciska Lindelauf¹, Heleen van Velzen-Blad², Thijs W Hoffman³ and Diana A van Kessel^3,4

¹Department of Sciences, University College Roosevelt, Netherlands
²Laboratory for Medical Microbiology and Immunology, St Antonius Hospital, Netherlands
³Department of Pulmonology St. Antonius Hospital, Netherlands
⁴Department of Heart and Lungs, University Medical Center Utrecht, Netherlands

^*Correspondance to: Ger T Rijkers 

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Abstract

A newborn child, who suffered from two episodes of bacterial meningitis, was found to have an absence of IgG. Loss of IgG via kidneys or intestines was excluded. Next the mother was investigated who turned out to be agammaglobulinemic. IgG levels were below 1 g/L while IgM and IgA were normal. Mother was subsequently treated with gammaglobulin substitution therapy. The child produces normal levels of IgG and has remained infection free.

Citation:

Rijkers GT, Lindelauf C, van Velzen-Blad H, Hoffman TW, van Kessel DA. Adoration of the Magi: Agammaglobulinemia of the Mother, Clinically Expressed in her Child. Ann Clin Immunol Microbiol. 2018;1(1):1002.