Ann Clin Diabetes Endocrinol | Volume 4, Issue 1 | Research Article | Open Access

The Burden of Diabetic Kidney Disease in Nigeria- Systematic Review and Meta-Analysis

Taoreed Adegoke A1*, Oluwafemi E2, Busayo Isaac A3, Segun Peter A4 and Boluwatife Adeleye A5

1Department of Medicine, University College Hospital, Ibadan, Nigeria
2Alliance Hospital, Abuja, Nigeria
3Zenith Medical and Kidney Centre, Abuja, Nigeria
4Department of Medicine, University College Hospital, Ibadan, Nigeria
5College of Medicine, University of Ibadan, Ibadan, Nigeria

*Correspondance to: Taoreed Adegoke A 

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Background: Diabetic Kidney Disease (DKD) is a microvascular complication of diabetes mellitus. Considering that the burden of diabetes mellitus is rising in Nigeria, there is a need to ascertain the burden of one of its most common complications. The objective of the meta-analysis was to determine the pooled prevalence of DKD in Nigeria and identify its risk factors. Materials and Methods: The study is a meta-analysis and it followed the PRISMA guidelines. Google scholar, PubMed, AJOL, SCOPUS, medRxiv and the grey literature were systematically searched using appropriate key terms. Statistical analysis was done with Meta XL. The inverse variance heterogeneity model was used for the meta-analysis and heterogeneity was determined using the I2 statistic and the Cochran’s Q test. Publication bias was checked with the Doi plot and LFK index. Results: Nineteen studies met the eligibility criteria. The total sample size was 56,571. The pooled prevalence of diabetic kidney disease in Nigeria was 28% (95% CI 3-58). The Cochran’s Q was 747 (p<0.001) while the I2 statistic was 97.6%. The Doi plot was drawn and the LFK index was 6.22. The most common risk factors for DKD were suboptimal glycemic control, hypertension, and obesity, duration of diabetes, male gender and advancing age. Conclusion: The prevalence of DKD in Nigeria is high and greater attention should be focused on managing the risk factors so as to alleviate the burden of the disease


Diabetic kidney disease; Diabetic nephropathy; Prevalence; Risk factors; Metaanalysis


Taoreed Adegoke A, Oluwafemi E, Busayo Isaac A, Segun Peter A, Boluwatife Adeleye A. The Burden of Diabetic Kidney Disease in Nigeria- Systematic Review and Meta-Analysis. Ann Clin Diabetes Endocrinol. 2021; 4(1): 1024.

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