Ann Clin Anesth Res | Volume 6, Issue 1 | Research Article | Open Access

Retrospective Study to Compare Lactate Levels after Using Plasmalyte vs. Sterofundin Intravenous Fluid Intra-Operatively in Patients Undergoing Hyperthermic Intraperitoneal Chemotherapy

Deepti Arora*, Shagun Bhatia Shah and Rajiv Chawla

Department of Anesthesiology, Rajiv Gandhi Cancer Institute and Research Centre, India

*Correspondance to: Deepti Arora 

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Background: During HIPEC, chemotherapeutic agent is instilled in peritoneal cavity at high temperatures, causing hemodynamic alterations. This can severely compromise perfusion and oxygenation of tissues. As serum lactate is a biomarker of significant systemic tissue hypoperfusion, we have compared lactate levels after infusion of two different balanced crystalloid solutions, Plasmalyte (PL) and Sterofundin (SF). Methodology: Records of patients who underwent HIPEC surgery (June 2018 to February 2020) were evaluated retrospectively. Parameters including age, weight, total amount of SF and PL used intra operatively; pre-HIPEC and post-HIPEC lactate levels were noted. Patients were grouped as group PL and group SF. Primary outcome was to confirm if there was a significant increase in lactate levels due to infusion of any of two crystalloids. Secondary outcomes were differences in pH and electrolyte equilibrium in the two groups. Results: 41 patients were analyzed. More patients received PL as an intraoperative fluid (n=29) and not SF (n=12). There was no significant difference in increase in lactate levels in both groups (p=0.46). Significant difference was seen in pH post HIPEC between the two groups though both pH were within normal range. Pre-HIPEC and post-HIPEC electrolyte values were also found to be comparable. Conclusion: Both the balanced crystalloid solutions compared are equally good in terms of perfusion of tissues during HIPEC. Both the acetate based solutions maintained the acid base balance and electrolyte homeostasis.


HIPEC; Plasmalyte TM; Sterofundinď››; Lactate; Electrolyte


Arora D, Shah SB, Chawla R. Retrospective Study to Compare Lactate Levels after Using Plasmalyte vs. Sterofundin Intravenous Fluid Intra- Operatively in Patients Undergoing Hyperthermic Intraperitoneal Chemotherapy. Ann Clin Anesth Res. 2022; 6(1): 1046..

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