Ann Cardiovasc Surg | Volume 1, Issue 3 | Research Article | Open Access

Changes in Lactate and NUCB2/Nesfatin-1 Before, During and After Cardiopulmonary Bypass

Suna Aydin1,2*, Tuncay Kuloglu3, Suleyman Aydin4 and Mehmet Nesimi Eren5

1Cardiovascular Surgery Department, Health Science University, Turkey
2Department of Anatomy, Firat University, Turkey
3Department of Histology and Embryology, Firat University, Turkey
4Department of Medical Biochemistry, School of Medicine, Firat University, Turkey
5Department of Cardiovascular Surgery, Dicle University, Turkey

*Correspondance to: Suna Aydin 

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Background: The main objective of this prospective study is to examine the effects of cardiopulmonary bypass on NUCB2/Nesfatin-1 hormone and its relation to hemodynamic parameters and to find out whether aorta, LIMA and saphena tissues synthesize NUCB2/Nesfatin-1.
Methods: From the 15 patients who underwent cardiopulmonary bypass surgery, LIMA and aortic tissues are harvested by making of hole for proximal anastomosis of the saphenous graft, and blood samples were collected before anesthesia induction (T1), before bypass (T2), before (T3) and after (T4) removing the cross clamp, upon transfer to intensive care (T5) and at postoperative 24 (T6) and 72 hours (T7). NUCB2/Nesfatin-1 amounts in biological samples were determined according to ELISA method and NUCB2/Nesfatin-1 immunoreactivity in the aorta, Left Internal Mammary Artery (LIMA) and leg vein (saphena) tissues was identified by immune histochemistry. Hemodynamic parameters and lactate levels of the patients were also measured.
Results: Circulating NUCB2/Nesfatin-1 levels of the patients steadily increased from T1 to T3, but showed a gradual decrease after T4 (including T4). Lactate levels displayed parallel changes to nesfatin-1. Additionally, synthesis of NUCB2/Nesfatin-1 on the tunica media layer of human aorta, saphena and LIMA tissues was reported for the first time. Conclusions: considering that nesfatin-1 is synthesized in the human aorta, saphena and LIMA tissues and that the levels of this hormone have a parallel course with lactate levels in coronary artery bypass surgery, it can be a new parameter for use when monitoring coronary artery surgery.


Lactate; NUCB2/Nesfatin-1; Cardiopulmonary bypass


Aydin S, Kuloglu T, Aydin S, Eren MN. Changes in Lactate and NUCB2/ Nesfatin-1 Before, During and After Cardiopulmonary Bypass. Ann Cardiovasc Surg. 2018; 1(3): 1012.

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