Ann Cardiol Cardiovasc Med | Volume 7, Issue 1 | Case Report | Open Access

Tirofiban Induced Severe Thrombocytopenia with Spontaneous Recovery

Ahmad B^1*, Shaukat T¹, Rehman W2,3 and Muneeb A^2,3

¹Department of Internal Medicine, King Edward Medical University, Pakistan ²Department of Internal Medicine, United Health Services Hospitals, Wilson Regional Medical Center, USA ³Department of Cardiology and Cardiovascular surgery, United Health Services Hospitals, Heart and Vascular Institute, Wilson Regional Medical Center, USA

^*Correspondance to: Behrawar Ahmad 

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Abstract

GPIIb/IIIa inhibitors (e.g., Tirofiban, abciximab, and eptifibatide) are associated with rapid onset thrombocytopenia, occurring within minutes to hours after exposure. This is an intriguing case of Tirofiban-induced thrombocytopenia with platelet count dropping from 254 × 103/uL at baseline to 4 × 103/uL in 12 h after initiation of Tirofiban infusion. The drug was immediately discontinued and platelet count recovered quickly and spontaneously, reaching the normal range within the following 24 h. This case of Tirofiban-induced thrombocytopenia emphasizes the importance of regular platelet count monitoring when administering GPIIb/IIIa inhibitors especially tirofiban and the importance of recognizing and promptly managing such complications in the hospital setting.

Keywords:

Thrombocytopenia; Platelet dysfunction; Antiplatelet therapy; GPIIb/IIIa inhibitors; Tirofiban

Citation:

Ahmad B, Shaukat T, Rehman W, Muneeb A. Tirofiban Induced Severe Thrombocytopenia with Spontaneous Recovery. Ann Cardiol Cardiovasc Med. 2023; 6(1): 1051..