Ann Atheroscler Res | Volume 2, Issue 1 | Review Article | Open Access

Role of Triglycerides and HDL for Residual Risk in Patients with LDL Cholesterol at Goal

Jesús E Millán Núñez-Cortés* and Joaquin J Millán Pérez

Department of Medicine, Complutense University of Madrid, Spain

*Correspondance to: Jesús E Millán Núñez-Cortés 

Fulltext PDF


Aim: To determine whether high triglycerides and/or low HDL-cholesterol in the presence of controlled LDL-cholesterol is related with cardiovascular disease and incident of coronary heart disease.
Methods: This study is a population-based case-control study with matching in gender and age; and was conducted in a university clinic. Cases had incident coronary heart disease, either acute myocardial infarction or acute coronary syndrome. Controls had diagnosis unrelated to coronary heart disease or other ischemic vascular disease. The cases and controls were patients who had LDL-cholesterol <130 mg/dL.
Results: Mean LDL-cholesterol was 91.25 mg/dL for cases and 99.30 mg/dL for controls. Statin treatment was used in 25.4% of cases and 22.3% in controls. The odds ratio of coronary heart disease was strongly and significantly associated with triglycerides concentration: 1.19 (1.10-1.28) per 30 mg/dL; and inversely associated with HDL-cholesterol: 0.71 (0.65-0.83) per 7.5 mg/dL.
Conclusion: High triglycerides and low HDL-cholesterol contributes strongly and independently to coronary heart disease in patients having LDL-cholesterol levels below 100 mg/dL. So, his contribution to residual vascular risk must be avoided in patients with controlled LDL-cholesterol.


JNúñez-Cortés EM, Millán Pérez JJ. Role of Triglycerides and HDL for Residual Risk in Patients with LDL Cholesterol at Goal. Ann Atheroscler Res. 2019;2(1):1014.

Subscribe to Our Newsletter