Am J Pharmacol | Volume 6, Issue 1 | Review Article | Open Access
Hari S*
Department of Pharmacology, Apollo College of Pharmacy, Anjora, India
*Correspondance to: Hari Sonwani
Fulltext PDFNumerous cellular processes, including the release of neurotransmitters and the contraction of muscles, are largely triggered and regulated by Ca2+ inflow via Ca2+ permeable ion channels. In addition, Ca2+ influx regulates cellular migration and proliferation, two mechanisms linked to cancer. This study focuses on calcium influx in breast cancer cells and discusses how future drugs for breast cancer therapy may be pharmacological modulators of particular Ca2+ influx channels. Certain breast tumors have altered expression of particular calcium permeable ion channels. Such alterations may occasionally be connected to the prognosis and subtype of breast cancer. These days, models both in vivo and in vitro have assisted in identifying particular Ca2+ channels that are crucial for the growth and invasiveness of cancerous breast cells. Nonetheless, additional research is still needed to fully understand several features of Ca2+ influx in breast cancer. These include figuring out the processes behind the changed expression and the best treatment plan to target breast cancer cells via particular Ca2+ channels. In the upcoming ten years, research should concentrate on the function of Ca2+ influx in mechanisms other than the migration and proliferation of breast cancer cells.
Breast cancer; Calcium channels; Calcium influx; Calcium signaling; Oncology
Hari S. Pharmacological Therapeutic Potential in Breast Cancer Through Calcium Influx Pathways. Am J Pharmacol. 2023; 6(1): 1037..