Am J Pharmacol | Volume 1, Issue 1 | Mini Review | Open Access

Enhancements in the Preclinical Investigation of DrugInduced Liver Injury

Harriet Gaskell^*

Department of Pathology, University of Illinois at Chicago, USA

^*Correspondance to: Harriet Gaskell 

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Abstract

Drug induced liver injury is a major problem for the pharmaceutical industry and health services. Yet 30% to 40% of human hepatotoxins go undetected during in vitro studies. Hence, more predictive in vitro liver models are a critical requirement for preclinical screening of compounds demonstrating hepatotoxic liability. Huge advancements have taken place over the last decade innovating cell culture techniques in order to improve function of predictability of in vitro toxicity models. This review summarizes some of the key advancements in models used for the preclinical investigation of drug-induced liver injury.

Citation:

Gaskell H. Enhancements in the Preclinical Investigation of DrugInduced Liver Injury. Am J Pharmacol. 2018;1(1):1002.