Am J Otolaryngol Head Neck Surg | Volume 5, Issue 8 | Research Article | Open Access

Important Notes about Prestina

Jan Myjkowski

Otolaryngology Clinic in Mielec, Poland

*Correspondance to: Jan Myjkowski 

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The OHC transmembrane protein responsible for the transport of chlorine and anions through the cell membrane has been recognized as a molecular engine according to numerous studies. The work performed in the form of OHC contractions is supplied with the energy of the electric potential of the cell membrane. On the cytoplazmatic side, prestin has a chloride and anion level sensor. Changes in the level of chlorine in the cell are associated with OHC depolarization, which affects the conformational changes of the transmembrane protein and cell contraction. The frequency of prestin’s conformational changes depends on depolarization and this depends on the work of ion channels of the lateral and lower OHC surfaces. The frequency of depolarization is limited by the time the cell’s ion channels work. If the magnitude of the membrane potential changes is constants, then there is a problem with amplifying the soft tones. The contraction is proportional to the membrane potential and depolarization. Each contraction of the OHC by pulling on the basilar membrane strengthens the vibration of the basilar membrane. There is no mechanism for regulating OHC contractions


Acoustic cells; Amplification; Receptor; Ionic canals


Myjkowski J. Important Notes about Prestina. Am J Otolaryngol Head Neck Surg. 2022;5(8):1207.

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