Am J Otolaryngol Head Neck Surg | Volume 5, Issue 1 | Case Report | Open Access

Primary Laryngeal Lymphoma: A Rare Case Report and Clinical Characteristics in Chinese Patients

Zhuo Fu, Wei Sun* and Xiaolin Zhu*

Department of Otolaryngology, The First Affiliated Hospital of Sun Yat-sen University, P.R. China

*Correspondance to: Wei Sun 

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Purpose: Primary laryngeal lymphoma is rare. To characterize the clinical features of this disease, we describe in detail a case of a natural killer T-cell lymphoma originating in the larynx. In addition, we performed a retrospective study of laryngeal lymphoma cases published in the Chinese language literature.

Materials and Methods: In our case study, we present the disease, disease history, personal history, family history, physical examinations, imaging investigations, and histopathological examinations, while the age, gender, symptoms, involvement site, pathological subtype, disease course, tumor morphology, treatment, follow-up, and outcomes are analyzed in the Chinese literature study.

Results: A total of 62 articles comprising 90 cases were included. The average patient age was 45, with a male-to-female ratio of 7:3. Hoarseness was the most common initial symptom. The majority of cases originated in the supraglottis and were derived from B cells. Because of the non-specific nature of the clinical manifestations and imaging scans, the diagnosis and further typing of laryngeal lymphomas depend on histopathological examination and immunohistochemistry.

Conclusion: Therefore, physicians should consider performing a biopsy when laryngeal neoplasms are encountered to ensure that the correct diagnosis is made.


Laryngeal lymphoma; Retrospective study; Chinese patients; Diagnosis


Fu Z, Sun W, Zhu X. Primary Laryngeal Lymphoma: A Rare Case Report and Clinical Characteristics in Chinese Patients. Am J Otolaryngol Head Neck Surg. 2022; 5(1): 1168..

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