Am J Otolaryngol Head Neck Surg | Volume 3, Issue 7 | Case Series | Open Access

Oral Myofibroma: Clinical Case Report

Anna Beatriz Caprini Monteiro de Castro1, Octávio Giacomin Pralon1, Antônio Matheus Henriques Nunes1, Alessandra Oliveira Ferrari Gomes2, Silvia Paula de Oliveira3 and Luisa Aguirre Buexm1,4*

1Medicine School, Faculdade de Medicina de Campos, Campos dos Goytacazes, Brazil
2Dental Service, Prefeitura da Cidade do Rio de Janeiro, Rio de Janeiro, Brazil
3Dental Service, Hospital Universitário Clementino Fraga Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro,
4Dental School, Universidade Federal Fluminense, Niterói, Brazil

*Correspondance to: Luisa Aguirre Buexm 

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Myofibroma is a rare mesenchymal benign spindle cell tumor consisting of myofibroblasts. In most cases it is solitary, and it can occur in any age group but it is more common until the fourth decade of life. It is a tumor most commonly originated from soft tissues, bones or internal organs, with predilection for the head and neck region. Clinically, the tumor appears as a painless mass with rapid growth, which in some cases can simulate malignancy. However, it is benign and the treatment of choice consists of surgical excision, with low chances of recurrence. Spontaneous regression can occur. The clinical case report in question was developed in a 79-year-old Caucasian female patient who underwent an incisional biopsy of a painless nodule in the mandibular vestibular gingiva. Histopathologically, it appeared as a tumor composed of interlacing bundles of spindle cells with tapered nuclei and eosinophilic cytoplasm. The tumor cells were positive for smooth muscle actin and vimentin, but negative for desmin in immunohistochemistry. The histopathological exam, with the aid of the immunohistochemistry technique, was conclusive for oral myofibroma. Mesenchymal lesions are infrequent in the mouth, especially at the age of the patient, which makes the case a
histopathological rarity. The purpose of this case report is to elucidate and better understand the clinical characteristics, treatment and prognosis of this tumor. This report also discusses the diagnostic method and the expected characteristics in histopathological and immunohistochemical exams.


Myofibroma; Oral; Soft tissue; Immunohistochemistry; Oral medicine


de Castro ABCM, Pralon OG, Nunes AMH, Gomes AOF, de Oliveira SP, Aguirre Buexm L. Oral Myo ibroma: Clinical Case Report. Am J Otolaryngol Head Neck Surg. 2020;3(7): 1112..

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