Am J Med Public Health | Volume 4, Issue 4 | Research Article | Open Access

Prevalence and Determinant of Adverse Drug Reactions among MDR-TB Patients Attending St. Peter’s TB Specialized Hospital, Addis Ababa, Ethiopia

Teshome HT¹, Sahlu D^2* and Jabo SA³

¹College of Health Science, Addis Ababa University, Ethiopia
²Department of Public Health, College of Health Science, Salale University, Ethiopia
³College of Health Science, Kotbe Metropolitan University, Ethiopia

^*Correspondance to: Degemu Sahlu 

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Abstract

Background: Tuberculosis is one of the major public health problems throughout the world. About 9.6 million people are estimated to have tuberculosis in 2014. From this, 480,000 cases were multidrug-resistant tuberculosis. There is a need to identify areas to be focused on and prioritized for subsequent and targeted interventions, so this study was aim to assess the prevalence and factors affecting adverse drug reactions among multidrug-resistant tuberculosis patients. Method: Institution-based cross-sectional study design was conducted. A total of 286 patient cards were included in the study. Data abstraction form was used. The data were collected by trained nurses who are the multidrug-resistant tuberculosis ward staff. Data were entered, cleaned, and checked using Epi Data version 4.6 statistical software and analyzed by SPSS version 23. Bivariate logistic and then multivariate logistic regression analyses were done. Result: The prevalence of Adverse Drug Reactions in this study was 169 (59.1%). Treatment outcome (AOR=10.012, 95% CI, (2.131-47.036)) and comorbidity (AOR=5.809, 95% CI (1.106-30.504)) was significantly associated with an adverse drug reaction. Conclusion and Recommendation: There was a high prevalence of adverse drug reactions among multidrug-resistant tuberculosis patients. Comorbidity and treatment outcome were the independent determinants. Adverse drug reaction management strategies should be strengthened for better treatment outcomes.

Keywords:

Adverse drug reaction; MDR-TB; Patients

Citation:

Teshome HT, Sahlu D, Jabo SA. Prevalence and Determinant of Adverse Drug Reactions among MDRTB Patients Attending St. Peter’s TB Specialized Hospital, Addis Ababa, Ethiopia. Am J Med Public Health. 2023; 4(4): 1050..