Am J Leuk Res | Volume 7, Issue 2 | Research Article | Open Access
Wen-Chi Y
1Department of Internal Medicine, Division of Hematology and Medical Oncology, Pingtung Christian Hospital, Taiwan 2School of Medicine, College of Medicine, National Sun Yat-sen University, Taiwan 3College of Nursing, Meiho University, Taiwan
*Correspondance to: Yang Wen-Chi
Fulltext PDFAcute Promyelocytic Leukemia (APL) is a hematological malignancy with abnormal clone of translocation between chromosome 15 and 17 (t(15;17)) and appearance of PML-RARα fusion gene. Extramedullary involvement of APL is rare and the most common site is central nervous system. It has been reported that a rheumatoid arthritis combined with APL and shown a rare side effect of retinoid acid (ATRA) and arsenic treatment related arthritis. In our review, there is no report showed arthritis with leukemia cells infiltration in APL before. Gouty arthritis attack typically showed hyperuricemia. However, around 10% to 49% patients with gout attack had normal serum uric acid level. Monosodium urate crystals in synovial fluid is still the golden standard to diagnose of acute gout attack. Here, we report a patient with leukemic arthritis, superimposed in gouty arthritis, as the initial presentation of APL. We analysis the synovial fluid and confirmed by positive finding of PML-RARα fusion gene using RT-PCR.
Wen-Chi Y. Leukemic Arthritis in Acute Promyelocytic Leukemia. Am J Leuk Res. 2024; 7(2): 1035..