Am J Gerontol Geriatr | Volume 1, Issue 1 | Research Article | Open Access
Congcong Liu, Xuehui Li, Chun Liu, Zhihao Wang, Zhen Zhang, Hong Zhang and Yanqiu Xing*
Department of Geriatrics, Qilu Hospital of Shandong University, China
*Correspondance to: Yanqiu Xing*
Fulltext PDFObjective: To study the changes in the levels of blood troponin T (cTnT), Insulin-like Growth Factor 1 (IGF-1), and the N-Terminal of the Prohormone Brain Natriuretic Peptide (NT-proBNP) to evaluate the efficacy and safety of levosimendan on chronic heart failure.
Methods: Seventy four hospitalized ageing patients stages III-IV of cardiac function and a left ventricular ejection fraction <40% was selected. Thirty eight were administered routine treatments; the remaining 36 patients were administered routine treatments plus levosimendan. Vital signs, clinical presentations, changes in hemodynamics, and levels of IGF-1, cTnT, and NT-proBNP were monitored before and at 72 hours after treatment.
Results: The clinical effective rate was 83.3% (30/36, treatment) and 55.3% (21/38, control); the difference was statistically significant (p<0.05). The IGF-1 levels increased, the cTnT levels decreased, and the NT-ProBNP levels decreased in the treatment and control groups, respectively, at 72 hours after treatment. Systolic blood pressure decreased, mean diastolic blood pressure decreased, and heart rate decreased in the treatment and control groups, respectively, at 72 hours after treatment. The incidence rate of adverse effects was not statistically significant between the 2 groups (P > 0.05).
Conclusion: Levosimendan could be effective in treating chronic congestive heart failure; blood levels of cTnT and IGF-1 could be used to accurately evaluate its efficacy and with better specificity than with NT-proBNP.
Levosimendan; cTnT; IGF-1; NT-proBNP; Heart failure
Liu C, Li X, Liu C, Wang Z, Zhang Z, Zhang H, et al. Evaluating the Efficacy of Levosimendan on Ageing Chronic Heart Failure Using Blood Levels of cTnT, IGF-1 and NT-proBNP. Am J Gerentol Geriatr. 2018; 1(1): 1003.