Ariel Y Gliksberg1*, Kiara A Tulla2, Allison Fraum3, Mohamed Hassan4, Steven Garzon4, Michael Bresler3, Thom Lobe2 and Mary Lou Schmidt1
1Department of Pediatrics, University of Illinois at Chicago, USA 2Department of Surgery, University of Illinois at Chicago, USA 3Department of Radiology, University of Illinois at Chicago, USA 4Department of Pathology, University of Illinois at Chicago, USAFulltext PDF
Background: Mesenchymal Chondrosarcoma is a rare high-grade tumor that affects mostly young adults and is comprised of a mixture of low-grade cartilaginous tumor cells as well as a primitive mesenchymal high-grade component. Most commonly, these tumors arise from the craniofacial bones but have been reported in ribs, vertebrae and long bones. However, they may be extraskeletal and have been reported mainly in the head and neck region (cranial dura most commonly), lower extremities and many other soft tissue locations. The most common types of mediastinal tumors are thymoma, thyroid disease, lymphoma, and mixed germ cell tumor, with approximately 50% found in the anterior mediastinum and 50% in middle or posterior mediastinum. There have only been 11 cases of a primary mediastinal mesenchymal chondrosarcoma reported, and only two of these occurred in the anterior mediastinum. Case Report: Here, we present a 17-year-old Hispanic female a primary anterior mediastinal mesenchymal chondrosarcoma. We describe pre-operative radiologic findings, the surgical techniques used to remove this large tumor, the confirmatory pathologic analysis and proposed systemic and radiation therapies. Conclusion: Mediastinal mesenchymal chondrosarcoma has been noted in the literature with only two prior cases being in the anterior mediastinum. This diagnosis may be under diagnosed. Given the paucity of uniform treatment regimens and clinical trials outcome data, it is difficult to determine exact prognosis and treatment recommendations.
Mesenchymal chondrosarcoma; Anterior mediastinum; Pediatric germ-cell tumors
Gliksberg AY, Tulla KA, Fraum A, Hassan M, Garzon S, Bresler M, et al. Extraskeletal Mesenchymal Chondrosarcoma in the Anterior Mediastinum- A Rare Event: Case Report and Review of the Literature. Oncol Case Report J. 2021;4(1):1033..