J Gynecol Oncol | Volume 3, Issue 5 | Case Report | Open Access

Vulvar Squamous Cell Carcinoma Following Fractionated Laser Therapy for Vulvar Lichen Sclerosus, a Case Report of a 24 Year Old Woman

Groenewegen KL^1*, Voss FO^1,2, van Beurden M¹, Zijlmans HJMAA¹ and Vermaat H³

¹Department of Gynecologic Oncology, The Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Netherlands
²Department of Pathology, Amsterdam University Medical Centers, Netherlands
³Department of Dermatology, Spaarne Gasthuis, Netherlands

^*Correspondance to: Karelina Lisanne Groenewegen 

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Abstract

Vulvar Lichen Sclerosus (LS) is a chronic inflammatory dermatosis, which can develop into Vulvar Squamous Cell Carcinoma (VSCC). Long-term and compliant treatment with ultra-potent topical corticosteroids can reduce or even prevent risk of malignant progression. We report a case of a 24 year old woman who received three cycles of non-ablative fractional laser therapy with the “Diva Tight Laser” (a combination of fractionated non-ablative CO2 laser and Erbium:YAG laser) for yet untreated LS. Six months later she was diagnosed with VSCC. To our knowledge, this is the first case that is reported of the development of vulvar carcinoma after laser treatment for LS. We emphasize the importance of correct management in patients with LS, as there is a potential risk of developing VSCC in case of incorrect treatment.

Keywords:

Lichen Sclerosus (LS); Vulvar Squamous Cell Carcinoma (VSCC); LS-VSCC; Ultra-Potent Topical Corticosteroids (UTCS); Fractionated CO₂ laser

Citation:

Groenewegen KL, Voss FO, van Beurden M, Zijlmans HJMAA, Vermaat H. Vulvar Squamous Cell Carcinoma Following Fractionated Laser Therapy for Vulvar Lichen Sclerosus, a Case Report of a 24 Year Old Woman. J Gynecol Oncol. 2020; 3(5): 1045.