Sun Y1, Zhu Z2, Liu Z3 and Chen Y1*
1Department of Surgical Oncology, Zhejiang University School of Medicine, China
2Department of Neurosurgery, Zhejiang University School of Medicine, China
3Department of Vascular Surgery, Zhejiang University School of Medicine, China
Objective: The retrospective study aimed to describe the prognostic value of lymph node biopsy and Positive Lymph Node Ratio (PLNR) in ductal carcinoma of the breast in situ with Micro-invasion (DCISM) patients. Methods: The 4,311 patients diagnosed as DCISM were selected from the surveillance, epidemiology, and end results database from 2004 to 2016. The Propensity Score Matching (PSM) method and Kaplan-Meier analysis (log-rank test) were performed to analyze the Overall Survival (OS) and Cancer-Specific Survival (CSS). Risk factors were identified by the univariable and multivariable Cox proportional hazards regression model. Results: Patients in the non-lymph node biopsy group had worse OS than lymph node biopsy group (P=0.001) but had no statistically significant impact on CSS (P=0.369). There was a better prognosis in PLNR <0.2 group than ≥ 0.2 group, showing statistically significant both on OS and CSS (P=0.004, and P=0.027). In multivariable Cox regression analysis, mastectomy was a positive factor on OS but a negative factor on CSS. Receiving radiation therapy and younger age (<50 years old) would benefit patients on OS, but receiving chemotherapy may increase risk in CSS. Conclusion: Our propensity model confirmed that lymph node biopsy had a positive impact on the OS. PLNR ≥ 0.2 might increase the mortality risk in DCISM patients.
Lymph node biopsy; Micro-invasion; Prognosis; Breast cancer; Propensity score matching
Sun Y, Zhu Z, Liu Z, Chen Y. Lymph Node Biopsy in Ductal Carcinoma of Breast In Situ with Micro-Invasion: A Propensity Score Matching Analysis. J Gynecol Oncol. 2020; 3(1): 1024.