J Gastroenterol Hepatol Endosc | Volume 4, Issue 4 | Review Article | Open Access
Corey B Moore
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*Correspondance to: Corey B Moore*
Fulltext PDFIntroduction: Irritable Bowel Syndrome (IBS) affects up to 1 in 5 individuals with morbidity similar to that for individuals with diabetes. It is defined by symptoms (rather than signs) and is classified as a functional somatic disorder by the psychiatric manuals DSM-5 and ICI-10. It is also associated with several psychiatric disorders. Despite this, there is a growing understanding and appreciation of how genetics, the gut and gut microorganisms contribute to the symptoms that define IBS. This paper critically reviews the known pathophysiology of IBS. Method: Literature review on the pathophysiology of IBS. Results: IBS is the result of central and gut dysfunction, both of which can affect the development and response of each other. Dysregulation of the communication between the two is also important. Gut microorganisms also appear to have an important role. Conclusion: More research is needed to better understand how the brain and gut develop, and how they interact with each other and their environment. This will help better target the treatment for patients with IBS.
Moore CB. Pathophysiology of Irritable Bowel Syndrome: A Review. J Gastroenterol Hepatol Endosc. 2019;4(4):1070.