J Dent Oral Biol | Volume 2, Issue 15 | Short Communication | Open Access

Prospects for the Application of Neural Crest Cells for the Periodontal Therapy

Atsushi Tomokiyo^1*, Sayuri Hamano², Daigaku Hasegawa¹, Hideki Sugii², Shinichirou Yoshida¹ and Hidefumi Maeda^1,2

¹Division of Endodontics, Kyushu University Hospital, Japan
²Department of Endodontology and Operative Dentistry, Faculty of Dental Science, Kyushu University, Japan

^*Correspondance to: Atsushi Tomokiyo 

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Abstract

Periodontal tissues are predominantly formed by ecto-mesenchymal cells derived from the neural crest during embryonic development. Neural Crest Cells (NCCs), a transient multipotent stem cell population that plays crucial roles in the tissue development, have been regarded as highly promising candidates for the periodontal tissue regeneration. Our previous study demonstrated the establishment of a multipotent clonal Periodontal Ligament (PDL) cell line termed cell line 1-17 that showed NCCs phenotypes. In addition, our studies also reported the generation of Neural Crest-Like Cells (NCLCs) from human PDL-derived Induced Pluripotent Stem Cells (iPSCs). This article discusses the application of cell line 1-17 and human PDL iPSC-derived NCLCs for the study of clinical periodontal therapy.

Citation:

Tomokiyo A, Hamano S, Hasegawa D, Sugii H, Yoshida S, Maeda H. Prospects for the Application of Neural Crest Cells for the Periodontal Therapy. J Dent Oral Biol. 2017; 2(15): 1091.