Int J Family Med Prim Care | Volume 1, Issue 3 | Short Communication | Open Access
Yonova D, Dimitrova V, Trendafilov I, Papazov V, Arabadjieva D and Velkova N
Department of Nephrology, University Hospital “Lozenetz”, Sofia, Bulgaria
Dialysis Center, Medical University, Sofia, Bulgaria
Anemia is a satellite symptom of advanced Chronic Kidney Diseases (CKD) and it is a quite multifactorial manifestation. Lower erythro-stimulating factors, uremic intoxication of the bone marrow and of the blood cells, iron deficit, reduced nutrition and affected protein absorption etc., are the factors causing renal anemia. Vitamin B12 and folic acid, as protein structures, are deficient in a number of patients with CKD and, are associated with anemia and neurological disorders. Vitamin B12 has a central role in homocysteine metabolism, and low vitamin B12 levels have been associated with higher homocysteine in patients with advanced chronic kidney disease. This study investigated homocysteine levels in elderly HD patients (older than 65 years), comparing them with younger than 65 years adults, and what is its relation to vitamin B12 status in hemodialysis patients. The results suggest that homocysteine levels are not different in elderly patients, but vitamin B12 and folic acid are lower in this population, probably because of increasing of gut atrophy in advanced age.
Homocysteine (HmC); Vitamin B12; Folic acid (Fol.Ac.); Chronic Kidney Disease (CKD); Anemia; Hemodialysis (HD)
Yonova D, Dimitrova V, Trendafilov I, Papazov V, Arabadjieva D, Velkova N. Comparative Study of Homocysteine and Vitamin B12 in Patients on Hemodialysis Younger or Older Than 65 Years. Int J Fam Med Prim Care. 2020; 1(3): 1012.