Martyna Elas1*, Małgorzata Szczygieł1, Katarzyna Jasińska-Konior1, Anna Kozińska1, Anna Markiewicz2 and Bożena Romanowska-Dixon2
1Department of Biophysics, Jagiellonian University, Poland 2Department of Ophthalmology, Jagiellonian University Medical College, PolandFulltext PDF
Background: Uveal Melanoma (UM) although a rare disease, causes high mortality due to metastases. Long-term prognosis may be estimated based on the genetic profile of the UM tumor, however, lack of effective and specific treatment prevents cure. Methods: This review summarizes current knowledge and outlines future directions relevant to UM metastatic disease. Results: The overall consensus is that UM micrometastases remain dormant for a number of years, before actively proliferating and becoming detectable clinically. The main site of UM metastases is the liver, constituting a very specific niche, and numerous molecular factors are involved in UM liver homing, like CXCL12-CXCR4. Conclusion: New avenues of research must include the mechanism of UM cells seeding from the primary tumor, homing to the liver, liver invasion, as well as UM cell dormancy.
Uveal melanoma; Metastasis; Liver niche; Dormancy
Elas M, Szczygieł M, Jasińska- Konior K, Kozińska A, Markiewicz A, Romanowska-Dixon B. Towards Liver: Selected Aspects of Uveal Melanoma Metastasis. Clin Oncol. 2020; 5: 1738.