Ann Stem Cell Res Ther | Volume 2, Issue 2 | Review Article | Open Access

GFI1B in Stem Cell Biology and Cancer

Anguita E^1*, Candel FJ², Chaparro A¹ and Roldán-Etcheverry JJ¹

¹Department of Hematology, Hospital Clinico San Carlos, IdISSC, Complutense University of Madrid, Spain
²Department of Microbiology, Hospital Clinico San Carlos, IdISSC, Complutense University of Madrid, Spain

^*Correspondance to: Anguita E 

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Abstract

GFI1B was identified by sequence homology with the oncogene GFI1 (Growth Factor Independence 1). Both GFI1 and GFI1B transcription factors have six C-terminal C2H2 zinc-fingers and an N-terminal SNAG (SNAIL/GFI1) transcriptional repression domain. While GFI1 is essential for neutrophil differentiation and is also necessary for B and T lymphopoiesis, GFI1B is required for development of erythroid and megakaryocytic lineages. However, mounting evidences indicate that GFI1B has also a prominent role in hematopoietic stem cell quiescence and, according to its function in cell differentiation and stem cell maintenance, in cancer. Here we will briefly review the last findings on these aspects.

Keywords:

GFI1B; Stem cell; Hematopoiesis; Cancer; Leukemia; Lymphoma

Citation:

Anguita E, Candel FJ, Chaparro A, Roldán-Etcheverry JJ. GFI1B in Stem Cell Biology and Cancer. Ann Stem Cell Res Ther. 2018; 2(2): 1013.