Anguita E1*, Candel FJ2, Chaparro A1 and Roldán-Etcheverry JJ1
1Department of Hematology, Hospital Clinico San Carlos, IdISSC, Complutense University of Madrid, Spain
2Department of Microbiology, Hospital Clinico San Carlos, IdISSC, Complutense University of Madrid, Spain
GFI1B was identified by sequence homology with the oncogene GFI1 (Growth Factor Independence 1). Both GFI1 and GFI1B transcription factors have six C-terminal C2H2 zinc-fingers and an N-terminal SNAG (SNAIL/GFI1) transcriptional repression domain. While GFI1 is essential for neutrophil differentiation and is also necessary for B and T lymphopoiesis, GFI1B is required for development of erythroid and megakaryocytic lineages. However, mounting evidences indicate that GFI1B has also a prominent role in hematopoietic stem cell quiescence and, according to its function in cell differentiation and stem cell maintenance, in cancer. Here we will briefly review the last findings on these aspects.
GFI1B; Stem cell; Hematopoiesis; Cancer; Leukemia; Lymphoma
Anguita E, Candel FJ, Chaparro A, Roldán-Etcheverry JJ. GFI1B in Stem Cell Biology and Cancer. Ann Stem Cell Res Ther. 2018; 2(2): 1013.