Yuzhi Jiang1*, Yiwen Niu2, Zhiyong Wang2, Fei Song1, Shuwen Jin1 and Jiaoyun Dong1
1Department of Plastic Surgery, Shanghai Jiaotong University School of Medicine, China
2Department of Burns and Plastic Surgery, Shanghai Jiaotong University School of Medicine, China
Scars result in aesthetic sequelae and functional disorder and increase social and personal economic burdens. However, this problem still has not been resolved. Clinical studies have demonstrated that scars often form when the deep dermis is injured, and in these situations, fat tissues are also involved, which suggests that fat tissues might play important roles in scar formation. The key cause of scar formation is the excess number of fibroblasts and myofibroblasts that occur during wound repair. Therefore, to repair the fat tissue and decrease the number of fibroblasts in the wound, fibroblast trans-differentiation into fat cells, which would decrease the number of fibroblasts and myofibroblasts in the wound, was explored. Scar fibroblasts and normal fibroblasts were chosen as experimental samples, and the cells were cultured in adipocyte differentiation medium that included both a Wnt inhibitor and Peroxisome Proliferator-Activated Receptor γ (PPARγ) agonist. After treatment, RT-PCR showed that myofibroblast differentiation was inhibited in the scar fibroblast groups, while myofibroblast differentiation was not inhibited in the normal fibroblast groups. These preliminary results suggested that fibrosis was inhibited after the treatment and showed that the
biological behavior of the scar fibroblasts changed, which could be beneficial for the inhibition of scar formation.
Keywords: Scar formation; Adipogenesis; Fibroblast; Wnt signal; Peroxisome proliferatoractivated receptor γ (PPARγ)
Jiang Y, Niu Y, Wang Z, Song F, Jin S, Dong J. Exploring a Novel Method to Inhibit Scar Formation. Ann Plast Reconstr Surg. 2019; 3(5): 1046..