Ann Pediatr Res | Volume 4, Issue 3 | Research Article | Open Access

Do Severe Complications Like Aneurysms from Kawasaki and Kawasaki-Like Infections Arise in Children with Underlying Articulo-Autonomic Dysplasia/Ehlers-Danlos Syndrome?

Golder N Wilson1* and Vijay S Tonk2

¹Department of Pediatrics, Texas Tech University Health Science Center, USA ²Departments of Pediatrics, Obstetrics & Gynecology and Pathology, Texas Tech University Health Science Center, USA

^*Correspondance to: Golder N Wilson 

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Abstract

A hypothesis is presented that some patients with severe Kawasaki or Kawasaki-like disease from COVID-19 may have underlying Ehlers-Danlos syndrome or related diseases in the arthritisadrenaline disorder category. Sign and symptom frequencies from 710 patients having standard evaluations for Ehlers-Danlos syndrome are compared to those cited in reviews of Kawasaki disease with parallels in eye complaints, rashes and reactive skin, swallowing and gastrointestinal difficulties, pulmonary disease, and joint pain or arthritis. Mast cell mediators including complement factors, interleukin, and immune factors like cluster of differentiation 40 that may show chronic changes in arthritis-adrenaline disorder/Ehlers-Danlos syndrome are elevated in Kawasaki along with the Von Willebrand Factor that shows mutation by genomic analysis in some Ehlers-Danlos patients. Outlined procedures for hypothesis support or refutation include clinical observation for finding of tissue laxity (hyper mobility-clumsiness, skin elasticity, and skeletal change) and those of reciprocal dysautonomia (gastrointestinal problems from irritable bowel/mast cell activation disorder) in Kawasaki-like patients. Genomic analyses of gene structure and epigenetic regulation focused on molecules mediating ED’s predispositions and Kawasaki inflammatory responses can provide additional testimony. The approach highlights new abilities to detect genetic and epigenetic factors that determine susceptibility to infection and, from their modulation by inflammation, promises new avenues of molecular therapy.

Keywords:

Arthritis-Adrenaline disorder; Ehlers-Danlos syndrome; Kawasaki disease; Dysautonomia; Mast cell activation disorder; Aneurysms; Irritable bowel disease

Citation:

Wilson GN, Tonk VS. Do Severe Complications Like Aneurysms from Kawasaki and Kawasaki-Like Infections Arise in Children with Underlying Articulo-Autonomic Dysplasia/Ehlers- Danlos Syndrome?. Ann Pediatr Res. 2020; 4(3): 1042..