Ann Orthop Musculoskelet Disord | Volume 1, Issue 3 | Case Report | Open Access
Diego Sales de Oliveira1, Rafael Giovane Misse1, Letícia Alves Perin1, Alexandre Moura dos Santos1, Jean Marcos de Souza1, Fernanda Rodrigues Lima1, Valéria Costa-Hong2, Luiz Aparecido Bortolotto2 and Samuel Katsuiuky Shinjo1*
1Department of Rheumatology, University of São Paulo, Brazil
2Department of Cardiology, University of São Paulo, Brazil
*Correspondance to: Samuel Katsuiuky Shinjo
Fulltext PDFBackground: To assess the effects of an exercise training program on endothelial function, arterial stiffness, disease status and physical capacity in a patient with hereditary inclusion body Myopathy linked to avalosin-containing proteinpGlyG97Glu gene mutation.
Methods: A 51-year-oldwhite female patient with only inclusion body Myopathy pheno type (without Paget disease of bone and frontotemporal dementia) was submitted to a 24-weeks aerobic and resistance training program.
Results: Endothelial function, aerobic capacity and muscle strength (i.e. bench press) were improved after 12-weeks. Aerobic capacity and endothelial function further improved after 24-weeks, whereas no alterations were observed for arterial stiffness. Moreover, there was no impairment on the clinical and laboratory parameters of the disease after 12- and 24-weeks. Main Findings: Exercise training proves safe and effective for improving endothelial function and increasing aerobic capacity, muscle strength and function in the patient.
Aerobic capacity; Exercise training; Inclusion body myopathy; Myopathy; Myositis
de Oliveira DS, Misse RG, Perin LA, dos Santos AM, de Souza JM, Lima FR, et al. Exercise Training Program Improves Endothelial Function and Physical Capacity in a Patient with Hereditary Inclusion Body Myopathy Linked to a Valosin-Containing Protein Pglyg97glu Gene Mutation. Ann Orthop Musculoskelet Disord. 2018;1(3):1015.