Ann Med Med Res | Volume 5, Issue 1 | Research Article | Open Access
Tiantian Jiao, Endong Ji, Yuanqi Wang, Xueqi Lin, Linghao Xu, Yuanzhen Jiang, Qi Zhang* and Jiming Li*
Department of Cardiology, East Hospital, Tongji University School of Medicine, Shanghai 200120, China
Fulltext PDFObjective: To investigate the association between 1-h OGTT glucose ≥ 11.1 mmol/L and the severity
of Coronary Artery Disease (CAD) in Chinese patients.
Methods: Coronary angiography and standard 75 g OGTT were performed on 120 patients with
coronary artery disease. The severity of CAD was assessed by using Gensini score.
Results: After adjustments for age and gender, the Gensini scores of NGTN were lower than that
of any other group (P<0.05). The levels of Lipoprotein-α (Lp-α), glycohemoglobin (HbA1C),
C-Reactive Protein (CRP) and Uric Acid (UA) were lower in NGTN groups than those of NGT1H
(P<0.05), while the Area Under the Curve of glucose (AUCg) of NGT1H was larger than those
of NGTN (P<0.05). The Insulinogenic Index (IGI) of NGT1H and DM1H was found to be lower
than that of NGTN and of DMN, respectively (P<0.05), however there was no significant difference
between NGTN and NGT1H, IGRN and IGR1H respectively as far as Oral Glucose Insulin
Sensitivity (OGIS) was concerned. In a linear stepwise regression analysis model, both 1 h glucose
and 2 h glucose showed significant positive correlations with Gensini scores (P<0.05).
Conclusion: One-hour hyperglycaemia is associated with coronary artery disease and may be a risk
factor for coronary artery disease in Chinese subjects.
Type 2 Diabetes mellitus; Coronary artery disease; Coronary angiography; Atherosclerosis; 1-hour hyperglycemia
Jiao T, Ji E, Wang Y, Lin X, Xu L, Jiang Y, et al. One-Hour Hyperglycaemia is Associated with Coronary Artery Disease in Chinese Subjects. Ann Med Medical Res. 2022; 5: 1042..